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Accomplishments Breaking News VOTE 2018 Blog
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Report Ineffective Vaccines Enhance Disease

Issued: 2018-03-12

Image Credits: Daniel Paquet, Flickr.

In the current debate over whether or not to legislate the removal of individual vaccine exemptions, the quality of the vaccines themselves gets little attention.

According to the CDC, mumps outbreaks are on the rise despite the fact that 94.6% of children in the U.S. have had two doses of MMR vaccine. To combat the situation, the CDC is considering adding a third dose of MMR to the recommended vaccine schedule.

In 2010, California experienced the largest pertussis epidemic since 1958. According to the CDC, the U.S. has experienced increased pertussis disease despite high levels of vaccine coverage. Researchers studying the pertussis outbreaks determined vaccine effectiveness dropped to less than 9% by four years, and that the quality of immunization waned so rapidly that little protection remained 2-3 years after vaccination.

Influenza vaccination has had no beneficial effect on flu mortality. The CDC indicates vaccine effectiveness has oscillated between 10-60% from 2005-2017, while systematic reviews show little to no benefit of inactivated influenza vaccines on flu morbidity.

It’s clear that some vaccines don’t work as well as advertised. And yet, instead of first making a vaccine with better effectiveness, the solution is to use the force of law to make everyone get more shots of the failing vaccine.

Even when significant vaccine failure rates for vaccines are acknowledged, the legislative solution remains fully supported. Concerns over the need for more effective vaccines are dismissed by apologetics pointing out that the current vaccines are better than nothing. The assumption is implicit: low immunity is better than no immunity. So, until a better vaccine comes along, accept the current shot at whatever level of immunity it provides. But the notion that any amount of antibodies is preferable to no antibodies at all, is dangerously wrong. The same exact antibodies that prevent disease at higher concentrations, can enhance the disease at lower concentrations.

Instead of preventing infection, the antibodies permit a more invasive spread of the virus into different cell types, enhancing the disease and making it worse than if the child had never been vaccinated. This phenomenon is called antibody-dependent enhancement of disease, and it is a potential problem for vaccines that induce low levels of antibodies.

It’s not just a theoretical concern. It has happened. Vaccine-induced disease enhancement occurred previously with a measles vaccine that produced low levels of immunity.

The effect of vaccine-induced disease enhancement has been seen in clinical trials for a since abandoned HIV vaccine.

The HPV vaccine exhibited the capacity to enhance HPV infections during clinical trials. Women who tested positive for vaccine HPV serotypes by PCR analysis, and were then administered the vaccine, were more likely to develop high-grade cervical lesions than the non-vaccinated control group. These observations have persisted beyond clinical trials, and antibody-dependent enhancement has been raised as a possible explanation.

It’s been known for decades that non-neutralizing influenza antibodies can augment the uptake of influenza A virus strains, but it wasn’t until recently that the phenomenon of disease enhancement for influenza vaccination was observationally proven.

In 2009, seasonal influenza vaccination increased the risk of pandemic influenza illness in those who received the vaccine.

This result was confirmed in four observational studies.  Antibody-dependent enhancement of disease has been proposed as the potentiating mechanism.

Vaccines sometimes do nothing ─ they cause no harm as they fail to protect the vaccine recipient from disease.

Sometimes vaccines do worse than nothing ─ they cause more cases, and more severe cases of disease in those who opt to be vaccinated. Low levels of antibodies cannot be viewed as less of a good thing. Ineffective vaccines are a bad thing.

They stimulate low-level immune responses that sometimes potentiate the exact diseases they were intended to prevent.


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